Solenna isn't a magic pill or a brain game with a health promise. It's an evidence-based way to know the risk factors you can change and train the cognitive skills the research points to — tracked over time. Here's exactly what that's grounded in.
Five bodies of evidence shape the product. We're inspired by them — Solenna itself is not a clinical trial, and we don't claim it is.
The standing Commission on dementia concluded that around 45% of dementia cases are associated with 14 modifiable risk factors across the life course — from blood pressure and hearing to activity, mood, and social contact. Your risk profile is built directly on these.
Livingston et al., The Lancet, 2024.A two-year multidomain lifestyle programme — diet, exercise, cognitive training, and vascular monitoring together — improved or maintained cognition in at-risk older adults versus control. This is why Solenna is a stack of levers, not one trick.
Ngandu et al., The Lancet, 2015.The largest and longest trial of cognitive training: ten supervised sessions in small groups, with follow-up running two decades. A ten-year analysis reported less dementia in the speed-of-processing arm, and that is why processing speed is weighted in the workout. It is weaker than it sounds, and the caveats matter more than the headline. Dementia was never a pre-specified outcome of the trial. Cases were counted using a screening definition rather than clinical diagnosis, and the trained task itself was among the measures that could qualify someone. And it has not replicated: no effect at five years, and none at twenty once outcomes were drawn from registry records. The drills are informed by this trial. They are not it, and no cognitive training has been shown to lower dementia risk.
Ball et al., 2002; Unverzagt et al., 2012; Rebok et al., 2014; Edwards et al., Alzheimer's & Dementia (TRCI), 2017; Coe et al., 2026.The LIBRA index (Deckers et al., 2015) is the weighted list your risk profile is actually scored against. It was built to rank modifiable factors for an individual, which the Lancet Commission's population estimate is not designed to do. An updated version with revised weights was published in 2024 and Solenna has not migrated to it yet. Naming it here because it does the scoring work and was previously the one source on this page we did not credit.
Deckers et al., Int J Geriatr Psychiatry, 2015; updated index, 2024.Intensive blood-pressure control significantly reduced the risk of mild cognitive impairment versus standard control. What's good for your heart is good for your brain — a core Solenna lever.
SPRINT MIND Investigators, JAMA, 2019.Our pledge, in plain terms: we say reduce risk, lower risk, delay onset, and may help. We never say prevent, cure, treat, reverse, or diagnose. Solenna is educational — it informs and helps you build habits linked to lower risk. It is not a medical device, a diagnosis, or a guarantee, and individual results vary.
If a claim can't be backed by the evidence above, we don't make it.
Free, private, no diagnosis. Your risk profile picks the levers that matter most for you.